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Answers to Liquid Glucosamine Questions

Get the Facts on Liquid Glucosamine and Synflex

Q. Why is Synflex® considered to be one of the most effective liquid glucosamine products on the market today?

A. We have taken the utmost care to ensure we provide the highest quality, most effective product. To do this, we use only the highest quality and purest ingredients. In fact, we use 98% pure liquid Glucosamine with ten other high quality synergistic arthritis-fighting ingredients in a premium formula developed for maximum absorption and relief. In addition, each batch of Synflex® undergoes a laboratory analysis to ensure ingredient quality and efficacy, plus it is issued a certificate of analysis.

You will absorb much more glucosamine (and other ingredients) than you would with products in pill or capsule form if it is pharmaceutical grade, high quality liquid glucosamine. As a result, most users are able to notice results in about 10-20 days, instead of 6-10 weeks (or not at all with capsules or low-grade liquid products.)


Q. Are there any side effects?

ASynflex® is a very safe product. There are a few things you need to know. Consult your doctor before taking glucosamine if you are currently pregnant or nursing. Current medical literature indicates that diabetics may use Synflex. However, you may wish to monitor your blood sugar levels or consult your physician.

If you are allergic to shellfish, you should monitor your reaction and discontinue if any adverse affects occur. A small percentage of people who take Glucosamine may encounter light diarrhea or stomach upset. This can be avoided by splitting the dosage between morning and evening. More information on side effects can be found here.

We do not recommend Synflex® 1500 for pets. Some cats and dogs are allergic to White Willow bark, an ingredient in Synflex® 1500. We recommend using Synflex® Original or Synflex® for Pets Beef Flavored.


Q. Does Synflex® interact with any drugs or medications?

A. We carry all-natural products and they typically should not interact with any drugs or medications. Synflex® 1500, on the other hand, contains White Willow bark. If you are taking medications that slow blood clotting, White Willow bark may react with these medications. We recommend Synflex® Original if you are taking these medications because it does not contain White Willow bark.


Q. Is Synflex® sold in stores?

A. Synflex® is sold in a number of health food stores, health clubs, hair salons, chiropractors offices, veterinarian offices, and the like. However, Synflex® is not available in any large retail stores at this time. We prefer to deal direct with our customers, and being the manufacturer of Synflex®, we are able to offer you the best price and mail you the product free of charge (in the United States). You can order online here via our secure server or if you are outside the United States, you can use the international order form.


Q. How can I buy Synflex®?

A. We accept credit cards, checks, and money orders. You can order online here via our secure server or if you are outside the United States, you can use the international order form. Call us toll free at 1-800-796-0142 or at (941) 778-2155 between 9am and 5pm EST Monday through Friday, or mail a check or money order to:

Synflex America, Inc. 
3849 Acline Road, Suite 300 
Punta Gorda, FL 33950  


Q. Why is better, stronger, healthier cartilage important?

A. When your cartilage is damaged, either as a result of primary osteoarthritis or flowing from an injury (secondary osteoarthritis), you will suffer the consequences. Since cartilage protects the bones from coming into contact with one another, the opposite result is extremely painful. In a great many cases, it can result in surgery.

As your cartilage begins to lose its “fluid-like” capabilities, the process of osteoarthritis begins. Whether the result of aging, genetics, overuse or injury, some 70 million Americans suffer from this debilitating condition. Whether you suffer from this condition or are trying to prevent it, every step that you can take to avoid the consequences is well worth it.


Q. What exactly IS Glucosamine?

A. Glucosamine is a charged sugar molecule that is a key component of the extracellular matrix of cartilage (grout between the cartilage cells). It absorbs and releases water with each step, thereby acting as a shock absorber for the joints. With more Glucosamine present, there is more joint protection.

Glucosamine is a natural sugar produced by your body. It is the essential and principal ingredient that determines the quantity of proteoglycans (water-holding) molecules that also form in the body. The greater the amount of Glucosamine in the body, the greater the amount of proteoglycans. The proteoglycans are large, water-binding molecules made up of (both) proteins and sugars. It is important to understand that they are a major building block of healthy, vital cartilage. Glucosamine also stimulates the production of glycosaminoglycans (GAG's), which are important proteins found in cartilage. They serve to "bind" the water within the cartilage matrix. Glucosamine supplements are made from the shells of shellfish. (More information on Glucosamine)


Q. Is Synflex® approved by the FDA?

A. Glucosamine products are nutritional supplements and are not regulated by the Food and Drug Administration (FDA). However, our laboratory is a cGMP certified facility that follows the guidelines of the FDA.


Q. Will I need to take this product daily for the rest of my life to keep my hip joint in repair or will I be able to reduce the dosage or even stop taking it at some point?

A. It is indeed advisable to maintain a daily dose of 1/4 oz. (1.5 teaspoons) per day. Those over 220 pounds or so may wish to maintain a higher dosage than this. For athletes, those using Syn-flex® as an arthritis easing measure, or those with mild arthritis, we recommend using the normal 1/4 oz. dosage. If you choose to reduce that dosage amount, if any pains return or cartilage continues to deteriorate, increase your dosage back to the suggested amount. We recommend taking a double dose (1/2 oz. per day) for the first 7-10 days.


Q. My friend is allergic to shellfish, but has been taking glucosamine for four years now without any problem. Can she take Synflex®?

A. Your friend can absolutely take Synflex®. As long as glucosamine hasn't been a problem in the past, Synflex® will be fine for her. The antigen in shellfish that causes an allergic reaction has been removed from Synflex®; nonetheless, we encourage you to consult with your physician before using Glucosamine. In fact, new research has shown that glucosamine is very unlikely to cause an allergic reaction in someone allergic to shellfish. In most cases, allergies are caused by proteins in shellfish, not chitin, a carbohydrate from which glucosamine is extracted. Furthermore, there is no crossover between the acid derived chitin from shells and the antigens that cause shellfish allergies since the acid process required to leach the chitin from the shell strips away the carbohydrate side chains that would be antigenic.


Q. I have never tried Synflex®. What does it taste like?

A. If you prefer, you can mix Synflex with your favorite drink. Some prefer to take a sip of water after using it. 

Synflex® Original for Pets, Athletes, & Arthritis – Berry flavored
Synflex® 1500 – Orange flavored
Synflex® for Pets Beef – Beef flavored


Q. Is it true that Synflex® will ease osteoarthritis pain in dogs, cats, and horses too?

A. Yes. Glucosamine was used to help with arthritis in horses many years before the beneficial effects for humans were known. Now with the high quality glucosamine, the liquid formula for maximum absorption, and the ten other beneficial ingredients, your dog or cat's arthritis or hip dysplasia can be alleviated with Synflex®.  More information on Synflex® glucosamine for pets can be found here.


Q. Do pets like the taste of Synflex®?

A. The large majority of dogs and cats like the flavor, and administration is very easy. You may need to put the Synflex® on a treat, mix it in with their food, or administer orally. We find that pouring the formula over food is most convenient approach for pets and their owners.


Q. What's the difference between Synflex® and Synflex® for Pets (original)?

A. In fact, they are the exact same product. The only difference is the dosage amount. The reason why we have separate "products" on the order form is so we can keep track of our sales. We also offer the beef flavor for pets.


Q. I am an athlete. Can Syn-flex® benefit me?

A. Absolutely. You can find more information on our website about glucosamine for athletes  and read success stories from our world class athlete sponsors.

Q. Who is Synflex America and how did you come up with Syn-flex®?


Synflex America was founded in 1999 by J.R. Rogers. In 1993, J.R. fell off a two story building and ended up with Spinal Stenosis and Secondary Arthritis in his neck. He tried pretty much everything he could find, but little helped and what did help often had very serious side effects. A friend of his was using a prototype liquid glucosamine to treat his thoroughbred horses and was using something very close to the Synflex® formula to ease arthritis in his horses. J.R. tried some of the formula and within four days he noticed that his pain had been significantly reduced. Within about 15 days, his inflammation had subsided and he had much greater mobility in his neck.


J.R. began passing out samples to his friends and they were astounded by the results they were getting. He knew that this product was one that belonged in the hands of everyone who suffered from OA. He founded Synflex America, Inc. Beginning in July, 2001, Synflex® was first made available to the general public worldwide. It has been an incredible success with a rapidly growing audience of direct purchasers and wholesale buyers. In fact, Synflex America is the largest direct-to-consumer retailer of liquid glucosamine in the world, distributing to over 100 countries.


Because pills and capsules are not absorbed as well as liquid glucosamine, you are not receiving as much glucosamine to your joints with pills and capsules or receiving it as quickly. Common sense tells you that you will receive more and faster relief from liquid glucosamine than from pills and capsules. Those who use a high quality liquid glucosamine formula can expect to notice results in about 7-14 days. As the pain eases, the liquid glucosamine also assists in the rehabilitation of the cartilage by renewing the supply of synovial fluid by producing the molecule nutrient protogylcans.


Q. I had knee surgery and lost half of my cartilage. How much of it can I rebuild and how?

A. Frankly, it is difficult to quantify the rehabilitation of cartilage by percentages. The cartilage that has been damaged may have simply lost its water-binding and water-holding capabilities. The glucosamine and chondroitin found in Synflex® stimulates the production of proteoglycans and glycosaminoglycans, restoring the cushioning properties of the cartilage and stopping bad enzymes from continuing to chew your cartilage away. It is safe to say that the rehabilitation would be quite dramatic. It does vary person to person and depends on the severity and progression of your arthritis.


Q. My doctor specifically recommended taking Synflex®. Are there many doctors who recommend Synflex®?

A. Many doctors are now recommending glucosamine, and many are indeed specifically recommending Synflex®. Generally, they either use Synflex® themselves or have heard great things about Syn-flex® from their patients. You can read a number of their testimonials in our success stories.


Q. I see that Synflex® contains both Glucosamine Sulfate and Glucosamine HCL. Why is Glucosamine HCL added to your product?

A. A medical study released in January of 2001 confirmed that Glucosamine Sulfate is clinically proven to assist those who suffer from arthritis. However, that is only part of the picture. Another medical study conducted several years ago compared the two ingredients. That study found the HCL form of Glucosamine created even more cartilage components and may have a higher bio-availability. We have combined both ingredients to ensure you benefit from both. In fact, Synflex® contains 1,250mg of glucosamine per daily ¼ oz. dose (in the Original formula). You can read more about Synflex® ingredients here.

Q. I have purchased Synflex®. What do you recommend for dosage?

A. We recommend ¼ oz per day for people. You may double the dosage for the first 7-10 days, but we do not recommend doubling the dosage after two weeks. Our Synflex® products come in a convenient, easy-to-use, dosage-accurate bottle. Usage instructions for the bottle can be found here.

We also offer a convenient dosage calculator to find the dosage for your pet, by weight.


Q. I know a lot of people who use it, and they all swear by it. What makes Synflex® so effective?

A. Certainly the ingredients themselves play a major role here. As well, it should be clear that a liquid formula is going to provide the greatest possible absorption into your system.


Q. What if there is NO cartilage left in a joint? What can Synflex® do?

A. When there is no cartilage left, Synflex® will help regenerate as much cartilage as is possible. However, when a bone on bone situation has occurred, that can be very challenging.

Synflex® will be your best shot at saving any cartilage that may be remaining and easing your pain. Additionally, if cartilage in one joint has disappeared, you should be taking liquid Glucosamine to protect other joints throughout your body.

If you are currently using NSAIDs or COX-2 Inhibitors, we would suggest not taking these as you are putting yourself at risk for many severe side effects. Furthermore, there is recent research suggesting taking these will actually hasten the deterioration of your cartilage.


Q. I have noticed that pills and capsules usually contain both Glucosamine and chondroitin. Does Synflex® have chondroitin in it?

A. Yes. The shark cartilage is comprised of approximately 20% chondroitin sulfate.


Q. Why do you use shark cartilage to derive the chondroitin sulfate in Synflex®?

A. The two most common compounds that are used for chondroitin are bovine (cow) trachea and shark cartilage. We chose to use shark cartilage over bovine due to the risk of BSE (Mad Cow Disease).


Q. I know that most joint products contain glucosamine. What are some of these other ingredients all about?

A. All of the ingredients contained in Synflex® are there because they assist in building healthy joints. Without going into a lot of detail about them, Boswellin, yucca, and omega 3 & 6 fatty acids each contribute to joint health and fight inflammation. Manganese and ascorbic acid are added to aid your body's ability to produce and absorb Glucosamine. You can read more about Synflex® ingredients here.


Q. Are there any special instructions other than what is on the label? Also, why are there slight changes in the color of the product?

A. Synflex does not have to be refrigerated. It has a shelf life of two years, so you can certainly store it at a room temperature for that long. A slight change in color happens sometimes. It is simply something that happens naturally as a result of exposure to light.


Q. I live outside the U.S. How can I purchase Synflex®?

A. We do ship Internationally. We provide shipping quotes for various shipping carriers at the checkout page upon ordering.  The shipping carriers consist of USPS, UPS, and DHL. Please contact us by email, LiveChat, or telephone if you are not ordering online and we would be happy to provide you with shipping information.


Q. Where can I find more information on glucosamine and arthritis?

A. Arthritis is a debilitating disease and it takes an active approach to easing it. We have a number of resources available for you to learn more about arthritis and the steps taken to effectively ease it.